Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation

Toward further implementation of continuous tablet manufacturing, one key issue is the time needed for start-up operation because it could lead to lower product yield and reduced economic performance. The behavior not well understood; moreover, definition still unclear. This work investigates effects process parameters on in wet granulation, which a critical unit solid drug manufacturing. profiles torque granule size distribution were monitored measured first hour operation, including phase. We analyzed impact based design experiments performed an assessment see operation. indicated that liquid-to-solid ratio screw speed would affect whereas different resulted size. Depending indicator used define optimal point was significantly different. results this study stress differs according definition, e.g., indicators criteria. aspect should be considered regulation